You can get the exclusive behaviour with random.randrange. (Relevant Stack Overflow question with a somewhat interesting answer)

Can’t resist pointing out how you should actually write the function in a “real” scenario (but still not handling errors properly), in case anyone wants to know.

If the list is guaranteed to have exactly two elements:

fn is_second_num_positive_exact(input: &str) -> bool {
    let (_, n) = input.split_once(',').unwrap();
    n.parse::<i32>().unwrap() > 0
}

If you want to test the last element:

fn is_last_num_positive(input: &str) -> bool {
    let n = input.split(',').next_back().unwrap();
    n.parse::<i32>().unwrap() > 0
}

If you want to test the 2nd (1-indexed) element:

fn is_second_num_positive(input: &str) -> bool {
    let n = input.split(',').nth(1).unwrap();
    n.parse::<i32>().unwrap() > 0
}

I can imagine Berdly Deltarune trying to explain this to Kris and Noelle in roughly this tone of voice.