Not really. It causes them stress. “Safe” and “Humane” are variable. But it definitely isn’t the “best” restraint method.
lifting and holding by the tail, and handling using a soft plastic restraint cone, resulted in significant increases in mean arterial pressure and heart rate compared with baseline.3 The authors concluded that being lifted in a restraint cone appeared to be the most disturbing handling method for the rats, followed by the tail method, as determined by prolonged duration of increased cardiovascular parameters as compared with the encircling or scruffing methods.3
Not really. It causes them stress. “Safe” and “Humane” are variable. But it definitely isn’t the “best” restraint method.
As for example explored by this paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC10844733/