Here you go:

with-lock-ex -q /path/to/lockfile sh -c '
while true; do
    crontab cronfile;
    sleep 60;
done;'

That’s why there’s a crontab rule to load the crontab from a file. Cronception if you will.

I always turn these around and ask given the study size, what is the confidence interval of the number of autism diagnoses attributable to Tylenol?

Often the number is surprisingly low given the other factors (and frequently uncontrolled confounders.)